They suggest that it could serve as a target for future treatments that may be used instead of — or in addition to — therapies that prostate cancer eventually becomes resistant to.
A paper now published in the journal Nature Genetics reports how blocking the gene — called AR-regulated long noncoding RNA 1 (ARLNC1) — killed cancer cells in prostate cancer cell lines.
Silencing ARLNC1 also shrank tumors in mouse models of prostate cancer, while increasing its expression made tumors grow larger.
Prostate cancer develops when cells grow out of control in the prostate, which is a gland that adds fluid to semen as it passes through the urethra in a man's body. In the United States, prostate cancer is the second most common cancer in men.
Official estimates suggest that there will be 164,690 new cases of prostate cancer in the U.S. in 2018, accounting for 9.5 percent of all new cases of cancer.
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